Hospira issues a voluntary global recall of multiple lots of ketorolac tromethamine injection | American Pharmacists Association Skip to main content

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Hospira issues a voluntary global recall of multiple lots of ketorolac tromethamine injection Share This Page
  February 12, 2015Hospira announced a voluntary recall of multiple lots of ketorolac tromethamine injection, USP after customer reports of particular matter in glass vials. The particulate was identified as calcium-ketorolac crystals.

Hospira announced a voluntary recall of multiple lots of ketorolac tromethamine injection, USP after customer reports of particular matter in glass vials. The particulate was identified as calcium-ketorolac crystals. The lots being recalled were distributed from February 2013 to December 2014 in the United States and from January 2014 to July 2014 in Singapore. Although Hospira has not received any reports related to the particulate in these lots, the company has launched an investigation into the issue.

FDA Alert (02/11/2015)

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Comparative analytics of infusion pump data across multiple hospital systems Skip to main page content

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Comparative analytics of infusion pump data across multiple hospital systems Ann Christine Catlin, William X. Malloy?, Karen J. Arthur, Cindy Gaston, James Young, Sudheera Fernando and Ruchith Fernando

Ann Christine Catlin, M.Sc., is Senior Research Scientist, Rosen Center for Advanced Computing, Purdue University, West Lafayette, IN. William X. Malloy, M.S., Pharm.D., BCPS, is Clinical Coordinator, Pharmacy; and Karen J. Arthur, Pharm.D., BCPS, is Medication Safety Program Manager, Roudebush Veterans Affairs Medical Center, Indianapolis, IN. Cindy Gaston, Pharm.D., BCPS, is Medication Use Policy Analyst, University of Wisconsin Hospital & Clinics, Madison. James Young, Pharm.D., CPHQ, is Quality Assurance/Performance Improvement Pharmacist, Eskenazi Health, Indianapolis. Sudheera Fernando, B.S., is Senior Software Engineer, Rosen Center for Advanced Computing; and Ruchith Fernando, Ph.D., is a graduate from the computer sciences department at Purdue University. Address correspondence to Dr. Malloy (william.malloy2{at}va.gov). Abstract Purpose A Web-based analytics system for conducting inhouse evaluations and cross-facility comparisons of alert data generated by smart infusion pumps is described.

Summary The Infusion Pump Informatics (IPI) project, a collaborative effort led by research scientists at Purdue University, was launched in 2009 to provide advanced analytics and tools for workflow analyses to assist hospitals in determining the significance of smart-pump alerts and reducing nuisance alerts. The IPI system allows facility-specific analyses of alert patterns and trends, as well as cross-facility comparisons of alert data uploaded by more than 55 participating institutions using different types of smart pumps. Tools accessible through the IPI portal include (1) charts displaying aggregated or breakout data on the top drugs associated with alerts, numbers of alerts per device or care area, and override-to-alert ratios, (2) investigative reports that can be used to characterize and analyze pump-programming errors in a variety of ways (e.g., by drug, by infusion type, by time of day), and (3) “drill-down” workflow analytics enabling users to evaluate alert patterns—both internally and in relation to patterns at other hospitals—in a quick and efficient stepwise fashion.

Conclusion The formation of the IPI analytics system to support a community of hospitals has been successful in providing sophisticated tools for member facilities to review, investigate, and efficiently analyze smart-pump alert data, not only within a member facility but also across other member facilities, to further enhance smart pump drug library design.

Copyright ? 2015 by the American Society of Health-System Pharmacists, Inc. All rights reserved. CiteULike Delicious Digg Facebook Google+ Reddit Twitter What's this?

? Previous | Next Article ? Table of Contents This Article doi: 10.2146/ajhp140424 American Journal of Health-System Pharmacy February 15, 2015 vol. 72 no. 4 317-324 ? Abstract Full Text Full Text (PDF) Classifications Print Content Medication-Use Technology Services Email this article to a colleague Alert me when this article is cited Alert me if a correction is posted Alert me when eLetters are published Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager eLetters Submit an eLetter No eLetters published Citing Articles Load citing article information Google Scholar Articles by Catlin, A. C. Articles by Fernando, R. PubMed PubMed citation Articles by Catlin, A. C. Articles by Fernando, R. Related Content Load related web page information Social Bookmarking CiteULike Delicious Digg Facebook Google+ Reddit Twitter What's this?

Current Issue February 15, 2015, 72 (4) Alert me to new issues of American Journal of Health-System Pharmacy From the Cover RhOD immune globulin products for prevention of alloimmunization during pregnancy Sublingual tacrolimus as an alternative to oral administration for solid organ transplant recipients Economic burden of recurrent venous thromboembolism: Analysis from a U.S. hospital perspective Comparative analytics of infusion pump data across multiple hospital systems ABOUT AJHP SUBSCRIPTIONS FOR AUTHORS/REVIEWERS PERMISSION REQUESTS ADVERTISING EMAIL ALERTS (FREE) RSS FEEDS (FREE) HELP CONTACT US/FEEDBACK American Society of Health System Pharmacists Learning Center (CE) Store Meetings & Conferences ASHP Foundation MOST READ ARTICLES (Last 30 Days) Clinical practice guidelines for antimicrobial prophylaxis in surgery Therapeutic monitoring of vancomycin in adult patients: A consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists How to write a patient case report Treatment of poisoning caused by {beta}-adrenergic and calcium-channel blockers ? View all Most Read articles Advertisement ? 2015 by the American Society of Health-System Pharmacists. Terms of Use | Copyright Online ISSN: 1535-2900 Print ISSN: 1079-2082

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Desensitization to ceftaroline in a patient with multiple medication hypersensitivity reactions Skip to main page content

HOME CURRENT ISSUE PAST ISSUES SUPPLEMENTS REPRINTS ALERTS KEYWORDS GO Advanced Search ? Advertisement
Desensitization to ceftaroline in a patient with multiple medication hypersensitivity reactions Justin M. Jones, Lisa M. Richter, Augusto Alonto and David D. Leedahl?

Justin M. Jones, Pharm.D., is Postgraduate Year 1 Pharmacy Resident; Lisa M. Richter, Pharm.D., BCPS, is Postgraduate Year 1 Pharmacy Residency Director; Augusto Alonto, M.D., is Infectious Disease Physician, Division of Infectious Diseases; and David D. Leedahl, Pharm.D., BCPS, is Clinical Pharmacy Manager, Sanford Medical Center, Fargo, ND. Address correspondence to Dr. Leedahl (david.leedahl{at}sanfordhealth.org). Abstract Purpose The case of a patient with multiple medication hypersensitivity reactions and a methicillin-resistant Staphylococcus aureus (MRSA) infection who underwent desensitization to ceftaroline is reported.

Summary A 32-year-old Caucasian woman with asthma, gastroesophageal reflux disease, heart murmur, and major depression was admitted for MRSA cellulitis with a subcutaneous abscess along the left sternomanubrial joint and clavicular osteomyelitis secondary to port placement after gastric bypass surgery. The patient had an extensive history of hypersensitivity reactions. Pertinent documented allergies were as follows: penicillin (anaphylaxis), daptomycin (anaphylaxis), vancomycin (hives), linezolid (hives), ertapenem (rash), ciprofloxacin (rash), and tigecycline (rash). The patient also reported previous reactions to aztreonam (unknown) and gentamicin (hives). The pharmacy was consulted to develop a desensitization protocol for ceftaroline. The desensitization protocol used three serial dilutions of ceftaroline to make 14 sequential infusions with escalating doses. Intramuscular epinephrine, i.v. diphenhydramine, and i.v. methylprednisolone were ordered as needed for the development of immediate hypersensitivity reactions during or after administration of ceftaroline. The cumulative dose (574.94 mg) was administered intravenously over 225 minutes with no breakthrough symptoms reported during or after the desensitization protocol. Ceftaroline fosamil 600 mg i.v. every 12 hours was continued for six weeks.

Conclusion Desensitization to ceftaroline was conducted for a patient with extensive history of hypersensitivity reactions to other drugs, including penicillin-induced anaphylaxis. Desensitization and subsequent treatment with full doses of ceftaroline were accomplished without apparent adverse effects.

Copyright ? 2015 by the American Society of Health-System Pharmacists, Inc. All rights reserved. CiteULike Delicious Digg Facebook Google+ Reddit Twitter What's this?

? Previous | Next Article ? Table of Contents This Article doi: 10.2146/ajhp140151 American Journal of Health-System Pharmacy February 1, 2015 vol. 72 no. 3 198-202 ? Abstract Full Text Full Text (PDF) Classifications Print Content Case Reports Services Email this article to a colleague Alert me when this article is cited Alert me if a correction is posted Alert me when eLetters are published Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager eLetters Submit an eLetter No eLetters published Citing Articles Load citing article information Google Scholar Articles by Jones, J. M. Articles by Leedahl, D. D. PubMed PubMed citation Articles by Jones, J. M. Articles by Leedahl, D. D. Related Content Load related web page information Social Bookmarking CiteULike Delicious Digg Facebook Google+ Reddit Twitter What's this?

Current Issue February 15, 2015, 72 (4) Alert me to new issues of American Journal of Health-System Pharmacy From the Cover RhOD immune globulin products for prevention of alloimmunization during pregnancy Sublingual tacrolimus as an alternative to oral administration for solid organ transplant recipients Economic burden of recurrent venous thromboembolism: Analysis from a U.S. hospital perspective Comparative analytics of infusion pump data across multiple hospital systems ABOUT AJHP SUBSCRIPTIONS FOR AUTHORS/REVIEWERS PERMISSION REQUESTS ADVERTISING EMAIL ALERTS (FREE) RSS FEEDS (FREE) HELP CONTACT US/FEEDBACK American Society of Health System Pharmacists Learning Center (CE) Store Meetings & Conferences ASHP Foundation MOST READ ARTICLES (Last 30 Days) Clinical practice guidelines for antimicrobial prophylaxis in surgery Therapeutic monitoring of vancomycin in adult patients: A consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists How to write a patient case report Treatment of poisoning caused by {beta}-adrenergic and calcium-channel blockers ? View all Most Read articles Advertisement ? 2015 by the American Society of Health-System Pharmacists. Terms of Use | Copyright Online ISSN: 1535-2900 Print ISSN: 1079-2082

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